2008 — 2014 PhD, Molecular and Cellular Biology
University of Maryland, College Park, MD
2006 — 2008 MSc, Biochemistry
George Washington University, Washington, DC
2004 — 2005 Undergraduate Exchange Student
Hebrew University, Jerusalem, Israel
2002 — 2006 Bachelor of Science (Honours)
Minor: English Literature
York University, Toronto, ON, Canada
University of British Columbia, 07/2015-Present
Postdoctoral fellow, Biochemistry Department
Advisor: Robert Molday, PhD
- Studying the role of lipid and retinoid transporters in inherited retinal degenerative diseases
- Currently building tissue culture models for studying ABCA4-mediated retinal transport
- Aim is to perform high-throughput screen for compounds that activate mutant forms of ABCA4, which are associated with Stargardt macular degeneration
University of Maryland College Park, 09/2008 — 06/2014
PhD candidate, Molecular and Cellular Biology Program
Advisor: Iqbal Hamza, PhD
- The Role of the ABC transporter, MRP5/ABCC5, in C. elegans heme homeostasis
- Analysis of heme transport capability by MRP5/ABCC5 protein from multiple species
- Analysis of role of MRP5/ABCC5 in mammals using knockout mice and mammalian tissue culture models
George Washington University, 09/2006 — 08/2008
MSc candidate, Biochemistry Program
Advisor: Ajit Kumar, PhD
Project: Role of miRNA-mediated repression of the DLC1 tumor suppressor in Hepatitis C-associated pathologies
York University, 09/2005 — 07/2006
Undergraduate honours research student, Biology Program
Advisor: John C. McDermott, PhD
Project: Role of p38γ kinase signaling in skeletal muscle differentiation
Korolnek T, Hamza I. Macrophages and iron trafficking at the birth and death of red cells. Blood. 2015 May 7; 125(19): 2893-7. Review. PubMed ID: 25778532.
Korolnek T, Hamza I. Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism. Frontiers in Pharmacology. 2014 Jun 4; 5:126. Review. PubMed ID: 24926267.
Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metabolism. 2014 Jun 3; 19(6): 1008-19. PubMed ID: 24836561.
Banaudha K, Kaliszewski M, Korolnek T, Florea L, Yeung ML, Jeang KT, Kumar A. MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes. Hepatology. 2011 Jan; 53(1): 53-61. PubMed ID: 20967756.
Banaudha K, Orenstein JM, Korolnek T, St Laurent GC 3rd, Wakita T, Kumar A. Primary hepatocyte culture supports hepatitis C virus replication: a model for infection-associated hepatocarcinogenesis. Hepatology. 2010 Jun; 51(6): 1922-32. PubMed PMID: 20512986.
Korolnek T, Zhang J, Scheffer GL, Hamza I (2014) A conserved function for MRP5 in coordinating systemic heme homeostasis. Presented at the FASEB Meeting on Trace Elements in Biology and Medicine (Steamboat, Colorado, USA).
Korolnek T, Hamza I (2013) An ABC transporter regulates systemic heme homeostasis in C. elegans. Presented at the International Worm Meeting (Los Angeles, California, USA).
Korolnek T, White C, Zhang J, Scheffer GL, Hamza I (2012) Control of metazoan heme homeostasis by a conserved ABC transporter-dependent efflux pathway. Presented at the Gordon Research Conference on the Chemistry and Biology of Tetrapyrroles (Newport, Rhode Island, USA).
Korolnek, T, Hamza, I (2011) HRG-9 regulates systemic heme homeostasis in C. elegans. Presented at the International Worm Meeting (Los Angeles, Californa, USA).
AWARDS AND HONOURS
- Poster Award, FASEB Conference on Trace Elements in Biology and Medicine Steamboat Springs, Colorado, USA (June 2014)
- Graduate Student Talk Award, Molecular and Cellular Biology Symposium, University of Maryland, College Park, USA (August 2013)
- Distinguished Teaching Assistant Award, Center for Teaching Excellence University of Maryland, College Park, USA (May 2010)
- Full scholarship for semester abroad, Canadian Friends of Hebrew University, Jerusalem, Israel (2004-2005)
- Dean’s List, York University, Toronto, Ontario, Canada (2004)
- Entrance Scholarship, York University, Toronto, Ontario, Canada (2002)
Experience editing multiple grants (including 2 NIH R01 grants), peer-reviewing multiple journal articles, writing two literature reviews, and publishing a first-author research paper
Western blotting, qPCR, genomic DNA isolation, genotyping, restriction enzyme and Gateway cloning, immunohistochemistry
Biochemical activity assays
Yeast maintenance, C. elegans transgenics, maintenance, and crosses, mouse maintenance and crosses, mammalian cell transformation and in vitro culture
Bright field, fluorescence, confocal, TIRF, and deconvolution
Animal Sciences Department, University of Maryland College Park, March 4, 2014
“Heme Biology and Diseases”
Guest lecture in “Nutritional Aspects of Metabolic Diseases” course
Graduate teaching assistant
Biology Department, University of Maryland College Park, 2008 — 2010
BSCI 105 Principles of Biology I Fall 2008, Spring/Fall 2009
BSCI 330 Cell Biology and Physiology Spring 2010
“Genome Geek”, Genomes: Unlocking Life’s Code
Smithsonian Museum of Natural History, Washington DC, June 2014
As a resident “geek”, I spoke to high school students from the Georgetown Summer Medical Institute program about the chemistry and biology of DNA and genomes, as well as discussing my own research and what life as a scientist is like.
MEMBERSHIPS AND EVENT PARTICIPATION
Executive Board Member UBC Postdoctoral Association (PDA), 2015-2016
Attendee NIDDK Mini-Symposium “The Role of Macrophages in Blood Cell Development”, February 2015
Member Baltimore-Washington C. elegans Club, 2009- 2015
Member Cell Biology and Genetics Journal Club, Animal Sciences Department, University of Maryland College Park, 2009-2015
Member Genetics Society of America, 2011-2014